FGF23 induces left ventricular hypertrophy

FGF23 induces left ventricular hypertrophy.

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 have been linked to greater risks of LVH and mortality in patients with CKD, but whether these risks represent causal effects of FGF23 is unkno...

Left Ventricular Hypertrophy Familial Predisposition of Left Ventricular Hypertrophy

METHODS Echocardiographic and anthropometric measurements were performed in 2,293 individuals who participated in the echocardiographic substudies of population-based MONICA Augsburg surveys. In addition, a total of 319 siblings of survey participants with echocardiographic evidence of LVH were evaluated. The risk of these siblings to present with LVH or abnormal LV geometry was estimated by co...

Cardiac FGF23 expression correlates with left ventricular hypertrophy in patients with chronic kidney disease

Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in children with CKD. Experimental and clinical studies demonstrated an association between elevated serum levels of fibroblast growth factor 23 (FGF23) and LVH in CKD. The aim of our study was to investigate i) the endogenous expression of FGF23 in heart tissue of paediatric CKD patients, ii) to establish the relationshi...

Left ventricular hypertrophy.

Left Ventricular Hypertrophy

The vectorcardiographic diagnosis of left ventricular hypertrophy, using the Frank lead system, was evaluated in 93 autopsied male patients (70 with hypertrophy of the left ventricle and 23 without such hypertrophy). The criterion of the maximal QRS magnitude in the transverse plane greater than 2.2 mv below the age of 50 years and 1.8 mv at the age of 50 or more was positive in 61% of hypertro...